Sex and regional disparities in incidence of hepatocellular carcinoma in autoimmune hepatitis: A systematic review and meta-analysis

Resource type: Publication Publication
  • Authors
    Yan L.-J.; Yao S.-Y.; Meng G.-X.; Liu K.-X.; Li H.-C.; Ding Z.-N.; Dong Z.-R.; Hong J.-G.; Chen Z.-Q.; Li T.
  • Type
    Original research
  • Journal
    Hepatology International
  • Publication Date
    2021
  • Abstract

    Background: Recent studies have identified an increased risk of hepatocellular carcinoma (HCC) in autoimmune hepatitis (AIH). Sex and regional disparities in incidence of HCC in AIH continue to be reported worldwide. Nevertheless, the magnitude of this gap remains unknown.

    Method(s): We searched several databases including PubMed, Embase, Web of Science, Cochrane Library, Wanfang Data, CNKI and SinoMed. Incidence rates of HCC in AIH were combined and analyzed following the EBayes method. Incidence rate ratios were pooled to assess the sex differences. The impact of population difference, sex, age, cirrhotic condition was further analyzed with subgroup analysis and linear regression analysis.

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