Gender differences in the prevalence of frailty in heart failure: A systematic review and meta-analysis

Resource type: Publication Publication
  • Authors
    Davis, Mary Roberts; Lee, Christopher S; Corcoran, Amy; Gupta, Nandita; Uchmanowicz, Izabella; Denfeld, Quin E
  • Type
    Original research
  • Journal
    International Journal of Cardiology
  • Publication Date
    2021
  • Abstract

    Objectives: This study quantitatively synthesized literature to identify gender differences in the prevalence of frailty in heart failure (HF).

    Background: The intersection of frailty and HF continues to garner interest. Almost half of patients with HF are frail; however, gender differences in frailty in HF are poorly understood.

    Methods: We performed a literature search to identify studies that reported prevalence of frailty by gender in HF. Random-effects meta-analysis was used to quantify the relative and absolute risk of frailty in women compared with men with HF, overall, and by Physical and Multidimensional Frailty measures. Meta-regression was performed to examine the influence of study age and functional class on relative risk in HF.

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