Sex differences in ketamine’s therapeutic effects for mood disorders: A systematic review

Resource type: Publication Publication
  • Authors
    Benitah, Katie; Siegel, Ashley N; Lipsitz, Orly; Rodrigues, Nelson B; Meshkat, Shakila; Lee, Yena; Mansur, Rodrigo B; Nasri, Flora; Lui, Leanna M W; McIntyre, Roger S; Rosenblat, Joshua D
  • Type
    Original Research
  • Journal
    Psychiatry Research
  • Publication Date
    2022
  • Abstract

    Replicated clinical trials have demonstrated rapid and robust antidepressant effects with ketamine in treatment resistant mood disorders. Sex (biological) and gender differences in therapeutic effects for any new intervention is an important consideration, however, the differential efficacy, safety and tolerability of ketamine in males versus females remains underexplored. The objective of the present systematic review is to identify and qualitatively synthesize all published clinical studies relevant to the sex differential effects of ketamine for mood disorders.

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