Regional and sex differences in the mortality risk associated with primary liver cancer in obesity: A systematic review and meta-analysis

Resource type: Publication Publication
  • Authors
    Yang, Long-Shan; Yan, Lun-Jie; Yan, Yu-Chuan; Ding, Zi-Niu; Liu, Hui; Tan, Si-Yu; Dong, Zhao-Ru; Wang, Dong-Xu; Li, Tao
  • Type
    Original research
  • Journal
    Nutrition
  • Publication Date
    2023
  • Abstract

    Objective: Obesity has increasingly become a prominent public health problem. Although some studies have shown that obesity is associated with the risk for primary liver cancer (PLC)-related mortality, the regional and sex differences are not clear. The aim of this meta-analysis was to further elucidate the influence of obesity on PLC prognosis from multiple aspects.

    Methods: This study used a systematic literature search on PubMed, Embase, Cochrane Library, Web of Science, Sinomed, and CNKI for eligible studies evaluating the effects of obesity on the prognosis of PLC. Data on PLC-related mortality, all-cause mortality, or recurrence should be available to obtain, and studies providing regional, or sex specificity are of concern. Hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were used to assess the pooled risk.

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