A deep transcriptome meta-analysis reveals sex differences in multiple sclerosis

Resource type: Publication Publication
  • Authors
    Català-Senent, José Francisco; Andreu, Zoraida; Hidalgo, Marta R.; Soler-Sáez, Irene; Roig, Francisco José; Yanguas-Casás, Natalia; Neva-Alejo, Almudena; López-Cerdán, Adolfo; de la Iglesia-Vayá, María; Stranger, Barbara E.; García-García, Francisco
  • Type
    Original research
  • Journal
    Neurobiology of Disease
  • Publication Date
    2023
  • Abstract

    Multiple sclerosis (MS), a chronic auto-immune, inflammatory, and degenerative disease of the central nervous system, affects both males and females; however, females suffer from a higher risk of developing MS (2-3:1 ratio relative to males). The precise sex-based factors influencing risk of MS are currently unknown. Here, we explore the role of sex in MS to identify molecular mechanisms underlying observed MS sex differences that may guide novel therapeutic approaches tailored for males or females.

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