Reference intervals of serum estradiol during childhood: Comparing and reviewing five studies, effects of gender and age

Resource type: Publication Publication
  • Authors
    Lamprecht T.; Reinehr T.; Kleber M.; Rothermel J.; Schulz E.; Simic-Schleicher G.; Heger S.; Holterhus P.-M.; Kulle A.
  • Type
    Original research
  • Journal
    Hormone Research in Paediatrics
  • Publication Date
    2022
  • Abstract

    Background: Specific measurement of low serum/plasma concentrations of 17beta-estradiol (E2) is important in pre-pubertal and pubertal children in routine paediatric endocrinology. However, there is still a gap in available reference intervals (RIs) for E2 in paediatrics. The study was partially funded by the German Ministry of Health, grant number 2519FSB503.

    Objective(s): First, we technically developed a highly sensitive LC-MS/MS method for E2. We then measured left-over control samples of 454 boys and 963 girls for calculation of RIs. Secondly, we performed a systematic review of published E2 RIs in children and adolescents. This was conducted by PubMed and Google scholar. Selection criteria were: a cohort size >700 and an age range covering the complete pediatric age range in both sexes.

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