Sex difference in the immunogenicity of the quadrivalent Human Papilloma Virus vaccine: Systematic review and meta-analysis

Resource type: Publication Publication
  • Authors
    Aldakak, Lafi; Huber, Vera Maria; Rühli, Frank; Bender, Nicole
  • Type
    Original research
  • Journal
    Vaccine
  • Publication Date
    2021
  • Abstract

    Background: Immunological differences between males and females in response to viral vaccines are well known. This the first review to examine them for the Human Papilloma Virus.

    Methods: We conducted a systematic review and meta-analysis of the immunogenicity of the Quadrivalent Human Papilloma Virus Vaccine qHPVV. We searched Medline, Embase, and CENTRAL for trials published until September 17, 2019. Inclusion criteria were 3-doses and reporting geometric mean titers (GMTs). We performed random-effects meta-analyses and meta-regression separated by age group and sex.

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