Sex differences in alpha-synucleinopathies: A systematic review

Resource type: Publication Publication
  • Authors
    Raheel K.; Deegan G.; Di Giulio I.; Cash D.; Ilic K.; Gnoni V.; Chaudhuri K.R.; Drakatos P.; Moran R.; Rosenzweig I.
  • Type
    Original Research
  • Journal
    Frontiers in Neurology
  • Publication Date
    2023
  • Abstract

    Past research indicates a higher prevalence, incidence, and severe clinical manifestations of alpha-synucleinopathies in men, leading to a suggestion of neuroprotective properties of female sex hormones (especially estrogen). The potential pathomechanisms of any such effect on alpha-synucleinopathies, however, are far from understood. With that aim, we undertook to systematically review, and to critically assess, contemporary evidence on sex and gender differences in alpha-synucleinopathies using a bench-to-bedside approach.

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